Cosmetic Ingredient Review

• Summary report
• Brief report
• Full report

The safety assessment summary report serves as a conclusion for each endpoint.

The brief report presents a brief description of each ingredient and concisely details the most reliable study available for each endpoint.

The full report presents the ingredients along with their toxicological data. Several studies are detailed for each endpoint. In the absence of toxicological data on the ingredient in the literature, a predictive toxicological evaluation is carried out. In silico tools (such as the QSAR – Quantitative Structure-Activity Relationship), read-across approaches and TTCs (Threshold of Toxicological Concern) are used to fill in any data gaps. The full report also includes an exposure assessment, characterization and risk management information.

We characterize the systemic toxicity risk related to the use of the ingredient via the application of a Margin of Safety (MoS). The MoS assigns a ratio to the hazard of an ingredient and a consumer’s exposure to it. The higher the ratio, the more the consumer is protected against potential systemic effects.

An evaluation of the consumer’s exposure to the ingredient can be made for a product category or can be tailored to your product and its specific properties. Consumer exposure depends on the concentration of the ingredient in the product and the use of the product.

If your ingredient is found to be a skin sensitizer, the QRA methodology is applied, which specifies the acceptable maximum concentration of the ingredient in the product or product category.

Together, these toxicological results allow us to draw conclusions regarding the safety of an ingredient for a given cosmetic product or product category.

The manufacturing method and any toxicological data regarding the raw material in which the ingredient is contained is a benefit for the safety assessment.

For the full report, the concentration of the ingredient in the cosmetic product and instructions for using the product are required for the exposure assessment.

With its experience in regulatory toxicology, BIORIUS evaluates the safety of your ingredients, including the safety of your complex natural extracts.