Omnibus Regulation 2019

Regulation of Several Hair and Eyelash Dyes

Numerous peer-reviewed articles highlighted the toxicity of hair dye substances and notably theirconcerning carcinogenic, genotoxic and skin sensitizing properties. Concerned by the potential risks for the consumers, the SCCS, the EU Commission, the Member States and the Industry developed an overallstrategy to evaluate a number of hair dye substances and, when necessary, regulate them via the annexes of the EU Cosmetics Regulation.

On the basis of this evaluation, the EU Commission published a new amendment (Regulation EU No 2017/237) of the Regulation, adding eight entriesto Annex III and updating two existing entries. The restrictions and warnings (that we invite you to consult via the link provided above) relate to the following ingredients:

Reference number Chemical name INCI name CAS EINECS
a b c d e
8c Ethanol, 2,2′-[(2-
N,N′-Bis(2-Hydroxyethyl)-2-Nitro-p-Phenylenediamine 84041-77-0 281-856-4
9b 1-Methyl-2,6-bis-
2,6-Dihydroxyethylaminotoluene 149330-25-6 443-210-1
298 Di[2-[4-[(E)-2-[4-
[bis(2-hydroxyethyl)aminophenyl]vinyl]pyridin-1-ium] butanoyl]aminoethyl]di-sulfanyl
HC Red No 17 1449471-67-3  
299 Di[2-[4-[(E)-2-
HC Yellow No
300 1H-Pyrazole-4,5-
diamine, 1-
hexyl-, sulfate
1-Hexyl 4,5-
Diamino Pyrazole Sulfate
301 4-Hydroxy-2,5,6-
triaminopyrimidine sulfate
302 2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethanol hydrochloride Hydroxyethoxy
Aminopyrazolopyridine HCl
303 Phenol, 3-amino2,6-dimethyl 3-Amino-2,6-
6994-64-5 230-268-6
304 2-Naphthalenaminium, 8-[(4-
amino-3-nitrophenyl)azo]-7-hydroxy-N,N,N-trimethyl-, chloride
Basic Brown 17 68391-32-2 269-944-0
305 3-Amino-7-(dimethylamino)-2-
methoxyphenoxazin-5-ium chloride
Basic Blue 124 67846-56-4 267-370-5

Furthermore, the definition of a hair product in the EU Cosmetics Regulation excludes an application on eyelashes*. A specific safety assessment was therefore needed for the application of hair dye substances on eyelashes and this amendment allows the use of five new ingredients:

* Which is not the case of eyebrows. In the EU, ‘Hair product’ means a ‘cosmetic product which is intended to be applied on the hair of head or face, except eye lashes’.

Reference number Chemical name INCI name CAS EINECS
a b c d e
200 2,4,5,6-Tetraaminopyrimidine sulphate Tetraaminopyrimidine Sulfate 5392-28-9 226-393-0
206 3-(2-Hydroxyethyl)- p-phenylenediammonium sulphate Hydroxyethyl-p Phenylenediamine Sulfate 93841-25-9 298-995-1
211 2-Aminopyridin3-ol 2-Amino-3- Hydroxypyridine 16867-03-1 240-886-8
243 1,3-Benzenediol,
2- methy
2-Methylresorcinol 608-25-3 210-155-8
272 4-Aminophenol p-Aminophenol 123-30-8 204-616-2

Please, note that the use of these eyelash dyes is restricted to professional products.
This piece of legislation will enter into force on March 2nd, 2017.

Any questions?


  • Frédéric Lebreux

    Dr. Frédéric Lebreux is Biorius's Chief Executive Officer and has worked in the cosmetic industry for more than 13 years. He is regularly invited as a speaker or Professor to cosmetic events.

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