Regulation of Several Hair and Eyelash Dyes

Numerous peer-reviewed articles highlighted the toxicity of hair dye substances and notably theirconcerning carcinogenic, genotoxic and skin sensitizing properties. Concerned by the potential risks for the consumers, the SCCS, the EU Commission, the Member States and the Industry developed an overallstrategy to evaluate a number of hair dye substances and, when necessary, regulate them via the annexes of the EU Cosmetics Regulation.

On the basis of this evaluation, the EU Commission published a new amendment (Regulation EU No 2017/237) of the Regulation, adding eight entriesto Annex III and updating two existing entries. The restrictions and warnings (that we invite you to consult via the link provided above) relate to the following ingredients:

Reference numberChemical nameINCI nameCASEINECS
abcde
8cEthanol, 2,2′-[(2-
nitro-1,4-phenylene)diimino]bis-
(9CI)
N,N′-Bis(2-Hydroxyethyl)-2-Nitro-p-Phenylenediamine84041-77-0281-856-4
9b1-Methyl-2,6-bis-
(2-hydroxyethylamino)-benzene
2,6-Dihydroxyethylaminotoluene149330-25-6443-210-1
298Di[2-[4-[(E)-2-[4-
[bis(2-hydroxyethyl)aminophenyl]vinyl]pyridin-1-ium] butanoyl]aminoethyl]
di-sulfanyl
dichloride
HC Red No 171449471-67-3
299Di[2-[4-[(E)-2-
[2,4,5-trimethoxyphenyl]vinyl]
pyridinin-1-ium]
butanoyl]aminoethyl]disulfanyl
dichloride
HC Yellow No
17
1450801-55-4
3001H-Pyrazole-4,5-
diamine, 1-
hexyl-, sulfate
(2:1)
1-Hexyl 4,5-
Diamino Pyrazole Sulfate
1361000-03-4
3014-Hydroxy-2,5,6-
triaminopyrimidine sulfate
2,5,6-Triamino4-Pyrimidinol
Sulfate
1603-02-7
3022-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethanol hydrochlorideHydroxyethoxy
Aminopyrazolopyridine HCl
1079221-49-0
303Phenol, 3-amino2,6-dimethyl3-Amino-2,6-
Dimethylphenol
6994-64-5230-268-6
3042-Naphthalenaminium, 8-[(4-
amino-3-nitrophenyl)azo]-7-hydroxy-N,N,N-trimethyl-, chloride
Basic Brown 1768391-32-2269-944-0
3053-Amino-7-(dimethylamino)-2-
methoxyphenoxazin-5-ium chloride
Basic Blue 12467846-56-4267-370-5

Furthermore, the definition of a hair product in the EU Cosmetics Regulation excludes an application on eyelashes*. A specific safety assessment was therefore needed for the application of hair dye substances on eyelashes and this amendment allows the use of five new ingredients:

* Which is not the case of eyebrows. In the EU, ‘Hair product’ means a ‘cosmetic product which is intended to be applied on the hair of head or face, except eye lashes’.

Reference numberChemical nameINCI nameCASEINECS
abcde
2002,4,5,6-Tetraaminopyrimidine sulphateTetraaminopyrimidine Sulfate5392-28-9226-393-0
2063-(2-Hydroxyethyl)- p-phenylenediammonium sulphateHydroxyethyl-p Phenylenediamine Sulfate93841-25-9298-995-1
2112-Aminopyridin3-ol2-Amino-3- Hydroxypyridine16867-03-1240-886-8
2431,3-Benzenediol,
2- methy
2-Methylresorcinol608-25-3210-155-8
2724-Aminophenolp-Aminophenol123-30-8204-616-2

Please, note that the use of these eyelash dyes is restricted to professional products.
This piece of legislation will enter into force on March 2nd, 2017.

Any questions?