{"id":48999,"date":"2021-02-26T00:00:00","date_gmt":"2021-02-25T23:00:00","guid":{"rendered":"https:\/\/biorius.com\/cosmetic-news\/%ed%99%94%ec%9e%a5%ed%92%88%ec%9d%98-%ed%8e%a9%ed%83%80%ec%9d%b4%eb%93%9c%ec%99%80-%eb%8b%a8%eb%b0%b1%ec%a7%88-2%eb%b6%80%ec%95%88%ec%a0%84-%ec%b8%a1%eb%a9%b4\/"},"modified":"2025-01-13T10:09:05","modified_gmt":"2025-01-13T09:09:05","slug":"%ed%99%94%ec%9e%a5%ed%92%88%ec%9d%98-%ed%8e%a9%ed%83%80%ec%9d%b4%eb%93%9c%ec%99%80-%eb%8b%a8%eb%b0%b1%ec%a7%88-2%eb%b6%80%ec%95%88%ec%a0%84-%ec%b8%a1%eb%a9%b4","status":"publish","type":"post","link":"https:\/\/biorius.com\/ko\/cosmetic-news\/%ed%99%94%ec%9e%a5%ed%92%88%ec%9d%98-%ed%8e%a9%ed%83%80%ec%9d%b4%eb%93%9c%ec%99%80-%eb%8b%a8%eb%b0%b1%ec%a7%88-2%eb%b6%80%ec%95%88%ec%a0%84-%ec%b8%a1%eb%a9%b4\/","title":{"rendered":"\ud654\uc7a5\ud488\uc758 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8 – 2\ubd80(\uc548\uc804 \uce21\uba74)"},"content":{"rendered":" \n

\uc18c\uac1c<\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\uc774\uc804 \ud30c\ud2b8\uc5d0\uc11c\ub294 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc774 \ud2b9\ud788 \ub178\ud654 \ubc29\uc9c0 \ud65c\ub3d9\uc73c\ub85c \uc778\ud574 \ud765\ubbf8\ub85c\uc6b4 \ud654\uc7a5\ud488 \uc131\ubd84\uc774\ub77c\ub294 \uc810\uc744 \uac15\uc870\ud588\uc2b5\ub2c8\ub2e4. \uc774\ubbf8 \uc218\ub9ce\uc740 \ud3a9\ud0c0\uc774\ub4dc \uae30\ubc18 \ud654\uc7a5\ud488 \uc6d0\ub8cc\uac00 \uc2dc\uc911\uc5d0 \ub098\uc640 \uc788\uc73c\uba70, \ub354 \ub9ce\uc740 \uc6d0\ub8cc\uac00 \uc9c0\uc18d\uc801\uc73c\ub85c \uc5f0\uad6c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\uc9c0\uae08\uae4c\uc9c0 \uc774\ub7ec\ud55c \uc131\ubd84\uc5d0 \ub300\ud55c \uaddc\uc81c\ub294 \uc8fc\ub85c \uc6d0\uc0b0\uc9c0(\uc778\uac04 \uc138\ud3ec \ubc0f \uae30\ud0c0 \uc720\uae30\uccb4\uc5d0\uc11c \ud569\uc131 \ub610\ub294 \ucd94\ucd9c\ud55c \uac83\uc774 \uc544\ub2cc\uc9c0 \uc5ec\ubd80) \ubc0f \ub9c8\ucf00\ud305 \ubb38\uad6c\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ub300\ubd80\ubd84\uc758 \uacbd\uc6b0 \uc774\ub7ec\ud55c \uc8fc\uc7a5\uc740 \uacbd\uc194\ud55c \uac83\uc774 \uc544\ub2c8\ub77c \ub69c\ub837\ud55c \uc0dd\ub9ac\uc801 \ud65c\ub3d9\uacfc \uade0\ud615\uc744 \uc774\ub8e8\uba70 \uc885\uc885 \uc870\uc0ac\ud574\uc57c \ud558\ub294 \ubd80\uc791\uc6a9\uc744 \ub3d9\ubc18\ud569\ub2c8\ub2e4. \uc774 \ubd80\ubd84\uc5d0\uc11c\ub294 \ud654\uc7a5\ud488 \uc6d0\ub8cc \ubc0f \uc81c\ud488\uc5d0 \uc0c8\ub85c\uc6b4 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc744 \uac1c\ubc1c\ud558\uac70\ub098 \uc0ac\uc6a9\ud560 \ub54c \uc778\uccb4 \uac74\uac15\uc5d0 \ub300\ud55c \uc704\ud5d8\uc744 \uc81c\ud55c\ud558\uae30 \uc704\ud55c \uba87 \uac00\uc9c0 \uc77c\ubc18\ud654\ub41c \uaddc\uce59\uacfc \ud568\uaed8 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc758 \uc548\uc804\uc131 \uce21\uba74\uc5d0 \ub300\ud574 \uc124\uba85\ud569\ub2c8\ub2e4.<\/p> \n \n

\ucc28\uc138\ub300 \uc131\ubd84\uacfc \uc774\uc804 \uc138\ub300 \uc131\ubd84 \ube44\uad50<\/strong><\/h2> \n \n

\ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc740 \uc7a0\uc7ac\uc801\uc778 \uc0dd\uccb4 \ud65c\uc131\uc73c\ub85c \uc778\ud574 \uc218\ub144 \ub3d9\uc548 \uc9d1\uc911\uc801\uc778 \uc758\ud559 \uc5f0\uad6c\uc758 \ub300\uc0c1\uc774 \ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uadf8 \ud2b9\uc131\uacfc \uc548\uc804\uc131\uc5d0 \uad00\ud55c \uce21\uba74\uc744 \ub3c4\ucd9c\ud558\uace0 \ud654\ud559\uc801\uc73c\ub85c \uc815\uc758\ub41c \uc800\ubd84\uc790\uc640 \ube44\uad50\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc218\uc2ed \ub144 \ub3d9\uc548 \uc0ac\uc6a9\ub41c \ub9ce\uc740 \uc131\ubd84\uc774 \ud654\ud559\uc801\uc73c\ub85c \uc815\uc758\ub41c \uc800\ubd84\uc790(\ub098\uc774\uc544\uc2e0\uc544\ub9c8\uc774\ub4dc, \ub808\ud2f0\ub180 \ub4f1)\uc778 \ubc18\uba74, \ucc28\uc138\ub300 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8(\uc131\uc7a5 \uc778\uc790, \ucf5c\ub77c\uac90 \uc11c\ube0c\uc720\ub2db \ub4f1)\uc774\ub77c\ub294 \uc810\uc5d0\uc11c \ud654\uc7a5\ud488\uacfc\ub3c4 \uc720\uc0ac\ud569\ub2c8\ub2e4.<\/p> \n \n

\ud45c 1: \uc800\ubd84\uc790\uc640 \ud3a9\ud0c0\uc774\ub4dc \ubc0f \ub2e8\ubc31\uc9c8\uc758 \ud504\ub85c\ud30c\uc77c \ube44\uad50<\/p> \n \n

\n
\"\"<\/figure> \n<\/div> \n \n

\uc704\uc5d0\uc11c \ubcfc \uc218 \uc788\ub4ef\uc774 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc740 \uc800\ubd84\uc790\uc5d0 \ube44\ud574 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uac1c\uc120\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\ub294 \uc5ec\ub7ec \uac00\uc9c0 \uace0\uc720\ud55c \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc81c\uc57d \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ud3a9\ud0c0\uc774\ub4dc \ubc0f \ub2e8\ubc31\uc9c8 \uc758\uc57d\ud488\uc740 \uae30\uc874\uc758 \uc800\ubd84\uc790 \uc758\uc57d\ud488\ubcf4\ub2e4 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc774 \ub354 \uc6b0\uc218\ud558\uace0 \ub0b4\uc57d\uc131\uc774 \ub354 \uc6b0\uc218\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ube60\ub978 \uc2e0\uc9c4\ub300\uc0ac\uc640 \uc548\uc815\uc131 \uc800\ud558\ub85c \uc778\ud574 \uc0dd\uccb4\uc774\uc6a9\ub960\uc774 \uac10\uc18c\ud558\ub294 \ub3d9\uc2dc\uc5d0 \ud45c\uc801\uc744 \ubc97\uc5b4\ub09c \ud6a8\uacfc\uac00 \uc801\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p> \n \n

\ud654\uc7a5\ud488 \ubc94\uc704\uc5d0\uc11c \uc774\ub7ec\ud55c \uc0dd\uccb4 \uc774\uc6a9\ub960 \uac10\uc18c\ub294 \uc548\uc804\uc131\uc5d0 \ub300\ud55c \uc704\ud5d8 \uac10\uc18c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \uc774\uc5d0 \ub300\ud55c \uadfc\uac70\ub294 \ub3c5\uc131\ud559\uc758 \ud575\uc2ec \uad50\ub9ac\uc785\ub2c8\ub2e4: “\uc6a9\ub7c9\uc774 \ub3c5\uc744 \ub9cc\ub4e0\ub2e4”\ub294 \ub3c5\uc131\ud559\uc758 \ub300\ubd80\ub85c \uc5ec\uaca8\uc9c0\ub294 \ud30c\ub77c\uc140\uc218\uc2a4 1500\uc758 \ub9d0\uc785\ub2c8\ub2e4. \uc800\ubd84\uc790\uc5d0 \ube44\ud574 \ud3a9\ud0c0\uc774\ub4dc \ubc0f \ub2e8\ubc31\uc9c8\uc758 \ub3c5\uc131 \uac10\uc18c\uc5d0 \ub3c4\uc6c0\uc774 \ub418\ub294 \ud2b9\uc131\uc740 \ub3c5\uc131 \ud3c9\uac00\uc9c0\ud45c\ubcc4\ub85c \uc544\ub798\uc5d0 \uc124\uba85\ub418\uc5b4 \uc788\uc73c\uba70, \uc774\ub7ec\ud55c \ud3c9\uac00\uc9c0\ud45c \uc911 \ub2e4\uc218\ub294 \ubaa8\ub4e0 \uc131\ubd84\uc5d0 \ub300\ud55c \ub3c5\uc131 \ud3c9\uac00\uc758 \uae30\ucd08\ub97c \ud615\uc131\ud569\ub2c8\ub2e4.<\/p> \n \n

\ud761\uc218, \ubd84\ud3ec, \ub300\uc0ac \ubc0f \ubc30\uc124<\/strong><\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\ud761\uc218, \ubd84\ud3ec, \ub300\uc0ac \ubc0f \ubc30\uc124(\ub610\ub294 ADME)\uc740 \uc678\uc778\uc131 \ubb3c\uc9c8\uc5d0 \ub300\ud55c \ub178\ucd9c\uc744 \uc815\uc758\ud558\ub294 \uc8fc\uc694 \uacfc\uc815\uc785\ub2c8\ub2e4. \ud654\uc7a5\ud488\uc744 \uace0\ub824\ud560 \ub54c, \ud654\uc7a5\ud488\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ud53c\ubd80\uc5d0 \ubc14\ub974\uace0 \ud53c\ubd80\ub294 \uc2e4\uc81c\ub85c \uc678\ubd80 \ubb3c\uc9c8\uc5d0 \ub300\ud55c \uc911\uc694\ud55c \uc7a5\ubcbd\uc774\ub77c\ub294 \uc810\uc744 \uace0\ub824\ud560 \ub54c \uc774\ub294 \uc8fc\ub85c \ud53c\ubd80 \ud761\uc218\uc5d0 \uc758\ud574 \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<\/p> \n \n

\ud53c\ubd80\ub294 \ub2e4\uc591\ud55c \uce35\uc73c\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\uc73c\uba70, \uac00\uc7a5 \uc704\uc5d0 \uc788\ub294 \uac01\uc9c8\uce35\uc740 \ub2e8\ub2e8\ud558\uac8c \ubc00\uc9d1\ub41c \uac01\uc9c8 \uc138\ud3ec\ub85c \uc774\ub8e8\uc5b4\uc838 \uc788\uc5b4 \ud06c\uace0 \uce5c\uc218\uc131 \ubb3c\uc9c8\uc758 \uce68\uc785\uc744 \ub9c9\ub294 \uc911\uc694\ud55c \uc7a5\ubcbd \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p> \n \n

\ud3a9\ud0c0\uc774\ub4dc\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ubd84\uc790\ub7c9\uc774 \ub192\uac70\ub098 \ub9e4\uc6b0 \ub192\uc73c\uba70 \uc77c\ubc18\uc801\uc73c\ub85c \uc0dd\ub9ac\uc801 pH\uc5d0\uc11c \ud558\uc804\ub418\uc5b4 \uce5c\uc218\uc131\uc744 \ub760\uae30 \ub54c\ubb38\uc5d0 \uc218\ub3d9\uc801\uc778 \ud53c\ubd80 \ud22c\uacfc\uc131\uc774 \ub5a8\uc5b4\uc9d1\ub2c8\ub2e4. \ub610\ud55c \ud3a9\ud0c0\uc774\ub4dc\uc5d0\ub294 \uc218\uc18c \uacb0\ud569 \ub3c4\ub108 \ubc0f \uc5b5\uc149\ud130 \uadf8\ub8f9\uc73c\ub85c\uc11c \uc5ec\ub7ec \uac1c\uc758 \uc544\ubbf8\ub4dc \uacb0\ud569\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\uc5b4 \ud53c\ubd80 \ud655\uc0b0\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\uace0\ub824\ud574\uc57c \ud560 \ub610 \ub2e4\ub978 \uce21\uba74\uc740 \ud53c\ubd80\uc758 \uc2e0\uc9c4\ub300\uc0ac\uc640 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \ud65c\ub3d9\uc774 \ud3a9\ud0c0\uc774\ub4dc\uc758 \uacbd\ud53c \uc804\ub2ec\uc5d0 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc911\uc694\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ud53c\ubd80\uc5d0\ub294 \uac04\uacfc \uac19\uc740 \ub2e4\ub978 \uc870\uc9c1\uc5d0\uc11c \ubc1c\uacac\ub418\ub294 \uac83\uacfc \ube44\uc2b7\ud55c \ud6a8\uc18c \uc2dc\uc2a4\ud15c\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ub370\uc544\ubbf8\ub098\uc81c, \uc5d0\uc2a4\ud14c\ub77c\uc544\uc81c, \uc544\ubbf8\ub178\ud3a9\ud2f0\ub2e4\uc81c\uc640 \uac19\uc740 \ub0b4\uc778\uc131 \ud6a8\uc18c\ub294 \ud53c\ubd80\uc758 \ubaa8\ub4e0 \uad6c\ud68d\uc5d0\uc11c \ubc1c\uacac\ub418\uba70 \uc774\ub7ec\ud55c \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc774 \ucc98\uc74c\uc5d0 \uac01\uc9c8\uce35\uc744 \ud1b5\uacfc\ud560 \uc218 \uc788\ub2e4\uace0 \uac00\uc815\ud558\uba74 \uc804\uc2e0 \uc21c\ud658\uc5d0 \ub4e4\uc5b4\uac00\uae30 \uc804\uc5d0 \ube60\ub978 \ub300\uc0ac\uc5d0 \uae30\uc5ec\ud558\ub294 \uac83\uc73c\ub85c \ucd94\uc815\ub429\ub2c8\ub2e4.<\/p> \n \n

\ub530\ub77c\uc11c \ud53c\ubd80\ub294 \uc774\ub7ec\ud55c \ubd84\uc790\uc758 \ud06c\uae30\uc640 \ud53c\ubd80\uc758 \ub300\uc0ac \ub2a5\ub825\uc5d0 \ub530\ub77c \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc5d0 \ub300\ud55c \uc911\uc694\ud55c \uc7a5\ubcbd \uc5ed\ud560\uc744 \ud558\ubbc0\ub85c \uc804\uc2e0 \ub178\ucd9c\uc774 \uc81c\ud55c\ub429\ub2c8\ub2e4. \uc774\ub97c \uac00\uc7a5 \uc798 \ubcf4\uc5ec\uc8fc\ub294 \uc608\ub294 \uc544\ub9c8\ub3c4 5\uac1c\uc758 \uc544\ubbf8\ub178\uc0b0\uc73c\ub85c \uc774\ub8e8\uc5b4\uc9c4 \ud3a9\ud0c0\uc774\ub4dc\uc784\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ud138\uc774 \uc5c6\ub294 \uc0dd\uc950 \ud53c\ubd80\uc758 \uc218\uc6a9\uccb4\uc561\uc774\ub098 \ud53c\ubd80\uce35(\uac01\uc9c8\uce35, \ud45c\ud53c, \uc9c4\ud53c)\uc5d0 \uc874\uc7ac\ud558\uc9c0 \uc54a\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc9c4 \ud39c\ud0c0\ud3a9\ud0c0\uc774\ub4dc-4(KTTKS)\uc758 \uacbd\uc6b0\uc77c \uac83\uc785\ub2c8\ub2e4(Choi et al., 2014).<\/p> \n \n

\uad11\ub3c5\uc131<\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\uad11\ub3c5\uc131 \uac00\ub2a5\uc131\uc740 \uc778\uc2e4\ub9ac\ucf54<\/em> \ud30c\ub77c\ubbf8\ud130\ub97c \uae30\ubc18\uc73c\ub85c \ud655\uc778\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6b0\uc120 \uc18c\uba78 \uacc4\uc218(\ubb3c\uc9c8\uc774 \ube5b\uc744 \ud761\uc218\ud558\ub294 \ub2a5\ub825)\ub294 \uc7a0\uc7ac\uc801 \uc704\ud5d8\uc131\uc744 \ub098\ud0c0\ub0b4\ub294 \uc9c0\ud45c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc18c\uba78 \uacc4\uc218\uac00 1,000 L mol-1 <\/sup> cm-1<\/sup> \ubbf8\ub9cc\uc778 \ubb3c\uc9c8\uc740 \uad11\ud761\uc218\uc728\uc774 \ub0ae\uc544 \uc720\ud574\ud560 \uac00\ub2a5\uc131\uc774 \ub0ae\uc73c\ubbc0\ub85c \uad11\ub3c5\uc131 \uc704\ud5d8\uc774 \uc801\uc740 \uac83\uc73c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4(Henry et al., 2009). \uc774 \uc758\uacac\uc740 IHC(\uad6d\uc81c\uc870\ud654\ud68c\uc758, 2013)\uc640 \uc720\ub7fd\uc758\uc57d\ud488\uccad(\uc720\ub7fd\uc758\uc57d\ud488\uccad, 2011)\uc5d0\uc11c\ub3c4 \uacf5\uc720\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\ud2b9\ud788 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc758 \uacbd\uc6b0, \ube5b\uc744 \ud761\uc218\ud558\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4 \uc544\ubbf8\ub178\uc0b0\uc778 \ud2f0\ub85c\uc2e0, \ud2b8\ub9bd\ud1a0\ud310, \uc2dc\uc2a4\ud14c\uc778 \uc794\ub958\ubb3c\uc758 \uc874\uc7ac\ub97c \uae30\ubc18\uc73c\ub85c \uc18c\uba78 \uacc4\uc218\ub97c \uc608\uce21\ud560 \uc218 \uc788\ub294 \uc6f9 \uae30\ubc18 \ub3c4\uad6c\uac00 \ub9ce\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud2f0\ub85c\uc2e0, \ud2b8\ub9bd\ud1a0\ud310, \uc2dc\uc2a4\ud14c\uc778 \uc794\ub958\ubb3c\uc744 \uc81c\ud55c\ud558\uba74 \ub2e8\ubc31\uc9c8 \ub610\ub294 \ud3a9\ud0c0\uc774\ub4dc\uc758 \uc18c\uba78 \uacc4\uc218\ub97c \uadfc\ubcf8\uc801\uc73c\ub85c \uc81c\ud55c\ud558\uc5ec \uad11\ub3c5\uc131 \uc704\ud5d8\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\uc720\uc804 \ub3c5\uc131<\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\uc77c\ubc18\uc801\uc73c\ub85c \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc740 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc720\uc804 \ub3c5\uc131\uc774 \uc788\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. ICH(\uad6d\uc81c\uc758\uc57d\ud488\uaddc\uc81c\uc870\ud654\uc704\uc6d0\ud68c)\ub294 \uac00\uc774\ub4dc\ub77c\uc778 \uc911 \ud558\ub098(ICH S6(R1))\uc5d0\uc11c “\uc774\ub7ec\ud55c \ubb3c\uc9c8(\ud3a9\ud0c0\uc774\ub4dc\/\ub2e8\ubc31\uc9c8)\uc774 DNA \ub610\ub294 \uae30\ud0c0 \uc5fc\uc0c9\uccb4 \ubb3c\uc9c8\uacfc \uc9c1\uc811 \uc0c1\ud638\uc791\uc6a9\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uc9c0 \uc54a\ub294\ub2e4<\/em>“\uace0 \uba85\uc2dc\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4(\uad6d\uc81c\uc870\ud654\ud68c\uc758, 2011). \uc774\ub294 78\uac1c\uc758 \ub2e8\ubc31\uc9c8\uc744 \ub300\uc0c1\uc73c\ub85c \uc720\uc804\ub3c5\uc131\uc744 \ud14c\uc2a4\ud2b8\ud55c \ub2e4\ub978 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \ud655\uc778\ub418\uc5c8\ub294\ub370, \ub2e8 4\uac1c\ub9cc\uc774 \uc7ac\ud604 \uac00\ub2a5\ud55c \uc720\uc804\ub3c5\uc131 \ud6a8\uacfc\ub97c \uc720\ubc1c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\uc774 \ud3a9\ud0c0\uc774\ub4dc \uc911 \ud558\ub098\uc758 \ud65c\uc131\uc740 \ub9c1\ucee4 \ubd84\uc790\uc5d0 \uae30\uc778\ud55c \ubc18\uba74, \ub098\uba38\uc9c0 3\uac1c\uc758 \ud3a9\ud0c0\uc774\ub4dc\ub294 \uc7a0\uc7ac\uc801\uc778 \ud6a8\uc18c\/\ud638\ub974\ubaac \ud65c\uc131\uc744 \uc81c\uc678\ud558\uace0\ub294 \uba85\ud655\ud55c \uadfc\uac70\ub97c \ud655\ub9bd\ud560 \uc218 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e4\uc81c\ub85c ‘\ud3c9\uade0\uc801\uc778’ \ub2e8\ubc31\uc9c8\uc758 \uacbd\uc6b0 \uce5c\uc218\uc131 \ubc18\uc751\uc740 \uc0c1\uc0c1\ud558\uae30 \uc5b4\ub835\ub2e4\ub294 \uacb0\ub860\uc774 \ub0b4\ub824\uc84c\uc2b5\ub2c8\ub2e4(Gocke et al., 1999).<\/p> \n \n

\uadf8\ub7fc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc77c\ubd80 \uc2dc\uc57d\uc740 \uc720\uc804 \ub3c5\uc131\uc774 \uc788\uc744 \uc218 \uc788\uc73c\ubbc0\ub85c \uc774\ub7ec\ud55c \ud3a9\ud2f0\ub4dc\uc640 \ub2e8\ubc31\uc9c8 \uc0dd\uc0b0\uc5d0 \uc0ac\uc6a9\ub418\ub294 \uc0dd\uc0b0 \uacf5\uc815\uc5d0 \uc0c1\ub2f9\ud55c \uc8fc\uc758\ub97c \uae30\uc6b8\uc5ec\uc57c \ud558\uba70, \uc7a0\uc7ac\uc801\uc778 \ubd80\uc0b0\ubb3c\uc774 \uc6d0\ub8cc\ub85c \uc774\uc6d4\ub418\ub294 \uac83\uc744 \uc81c\ud55c\ud558\uae30 \uc704\ud574 \uc0dd\uc0b0 \uacf5\uc815\uc5d0 \uc815\uc81c \ub2e8\uacc4\ub97c \ud1b5\ud569\ud574\uc57c \ud55c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p> \n \n

\ubbfc\uac10\uc131<\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\ud654\uc7a5\ud488\uc5d0 \ub300\ud55c \uac00\uc7a5 \uc911\uc694\ud55c \ubbfc\uac10\uc131 \ud53c\ubd80\uc5fc \uc720\ud615\uc740 4\ud615 \ubbfc\uac10\uc131 \ud53c\ubd80\uc5fc\uc73c\ub85c \ubd84\ub958\ub418\uba70 \ub300\ubd80\ubd84 T\uc138\ud3ec\uc640 \uad00\ub828\ub41c \uc811\ucd09\uc131 \ud53c\ubd80\uc5fc\uc785\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \ud53c\ubd80 \ubbfc\uac10\uc81c\ub294 \uc2dc\uc2a4\ud14c\uc778 \ubc0f \ub77c\uc774\uc2e0 \ub2e8\uc704\uc640 \uac19\uc740 \ub2e8\ubc31\uc9c8\uc758 \uce5c\ud575\uc131 \uadf8\ub8f9\uacfc \ubc18\uc751\ud560 \uc218 \uc788\ub294 \uce5c\uc720\uc804\uc131 \ubb3c\uc9c8\ub85c \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\ub610 \ub2e4\ub978 \uc911\uc694\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \uc790\uc720 \ub77c\ub514\uce7c \ubc18\uc751\uc5d0 \uae30\ubc18\ud569\ub2c8\ub2e4(Roberts et al., 2012). \uc870\uc0ac \ub300\uc0c1 \ud3a9\ud0c0\uc774\ub4dc\uc5d0\uc11c\ub294 \ub450 \uac00\uc9c0 \uc720\ud615\uc758 \ubc18\uc751\uc774 \ubaa8\ub450 \ubc1c\uc0dd\ud558\uc9c0 \uc54a\uc744 \uac00\ub2a5\uc131\uc774 \ub192\uace0 \ud574\ub2f9 \ud654\ud569\ubb3c\uc758 \ud761\uc218\uc728\uc774 \ub0ae\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\ubbc0\ub85c \ud53c\ubd80 \ubbfc\uac10\uc131 \uc704\ud5d8\uc740 \ub0ae\uc740 \uac83\uc73c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4.<\/p> \n \n

\uadf8\ub7ec\ub098 \uc2dd\ud488\uc5d0 \uc874\uc7ac\ud558\ub294 \ub9ce\uc740 \ub2e8\ubc31\uc9c8\uacfc \ud3a9\ud0c0\uc774\ub4dc\uac00 \uc54c\ub808\ub974\uae30 \uc720\ubc1c \ubb3c\uc9c8\ub85c\ub3c4 \uc791\uc6a9\ud55c\ub2e4\ub294 \uc810\uc744 \uace0\ub824\ud560 \ub54c \ud654\uc7a5\ud488\uc5d0 \uc0ac\uc6a9\ub418\ub294 \ub2e8\ubc31\uc9c8\uacfc \ud3a9\ud0c0\uc774\ub4dc\ub294 \uc774\ub7ec\ud55c \uc720\ud615\uc758 \uc54c\ub808\ub974\uae30 \uc720\ubc1c\uc131\uc5d0 \ub300\ud574 \ud3c9\uac00\ud560 \ud544\uc694\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ud2b9\ud788 \uc54c\ub808\ub974\uae30 \ubc0f \uc544\ub098\ud544\ub77d\uc2dc\uc2a4\uc640 \uac19\uc740 \uc989\uac01\uc801\uc778 \uacfc\ubbfc\uc99d\uc740 \uc811\ucd09\uc131 \ud53c\ubd80\uc5fc\uacfc\ub294 \ub2e4\ub978 \uba54\ucee4\ub2c8\uc998\uc744 \uc218\ubc18\ud569\ub2c8\ub2e4.<\/p> \n \n

1\ud615 \uac10\uc791\uc5d0\uc11c \uc774\ud399\ud130 \uc138\ud3ec\ub294 \ub300\ubd80\ubd84 \ube44\ub9cc \uc138\ud3ec \ubc0f IgE \ud56d\uccb4\uc640 \uac19\uc740 \ud56d\uccb4 \uc0dd\uc0b0 \uc138\ud3ec\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uac00\uc218 \ubd84\ud574 \ub41c \ubc00 \ub2e8\ubc31\uc9c8\uc5d0 \ub300\ud55c SCCS \ubc0f CIR\uc758 \uacfc\ud559\uc801 \uc758\uacac\uc5d0\uc11c \ubd84\uc790\ub7c9\uc774 3.5 kDa \ubbf8\ub9cc\uc778 \ud3a9\ud0c0\uc774\ub4dc\ub294 \uac10\uc791 \ub2a5\ub825\uc774 \ub0ae\ub2e4\ub294 \uac83\uc774 \ubd84\uba85\ud574\uc84c\uc2b5\ub2c8\ub2e4 (SCCS, 2014). \ub530\ub77c\uc11c 1\ud615 \uac10\uc791 \ubc18\uc751\uc774 \uc77c\uc5b4\ub098\ub824\uba74 \uc54c\ub808\ub974\uac90\uc774 \ub450 \uac1c\uc758 IgE \ud56d\uccb4\uc640 \uacb0\ud569\ud574\uc57c \ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc54c\ub808\ub974\uac90\uc740 \ucd5c\uc18c 15\uac1c \uc544\ubbf8\ub178\uc0b0 \uae38\uc774\uc758 IgE \uacb0\ud569 \ubd80\uc704\ub97c \uac01\uac01 2\uac1c \uc774\uc0c1 \ud3ec\ud568\ud574\uc57c \ud569\ub2c8\ub2e4. \uc774\ub294 \ub2e8\ubc31\uc9c8 \uc54c\ub808\ub974\uac90\uc758 \ucd5c\uc18c \ud06c\uae30\uac00 \uc57d 30\uac1c\uc758 \uc544\ubbf8\ub178\uc0b0\uc774\ub77c\ub294 \uac83\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4(Huby, 2000).<\/p> \n \n

\uc778\uccb4 \uac74\uac15\uc5d0 \ub300\ud55c \uc7a0\uc7ac\uc801 \uc704\ud5d8<\/strong><\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\uc704\uc5d0\uc11c \uc124\uba85\ud55c \ub0b4\uc6a9\uc744 \ubc14\ud0d5\uc73c\ub85c \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc5d0\ub294 \uc911\uc694\ud55c \ub3c5\uc131\ud559\uc801 \ud504\ub85c\ud544\uc774 \uc5c6\ub2e4\uace0 \uc0dd\uac01\ud560 \uc218 \uc788\uc9c0\ub9cc, \uc774\ub294 \uc798\ubabb\ub41c \uc0dd\uac01\uc785\ub2c8\ub2e4. \uc2e4\uc81c\ub85c \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc740 \uc0dd\uccb4\uc774\uc6a9\ub960\uacfc \uacfc\uc7a5\ub41c \uc57d\ub9ac\uc791\uc6a9\uc73c\ub85c \uc778\ud574 \uc778\uccb4 \uac74\uac15\uc5d0 \ud574\ub85c\uc6b8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc218\uc6a9\uccb4\uc640 \ud6a8\uc18c \ud615\ud0dc\uc758 \ub2e8\ubc31\uc9c8\uc740 \uc815\uc0c1\uc801\uc778 \uc2e0\uccb4 \uae30\ub2a5\uc744 \ucd09\uc9c4\ud558\ub294 \uae30\ub2a5 \ub2e8\uc704\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4. \uc2e0\ud638 \ubd84\uc790\ub97c \ud3ec\ud568\ud558\ub294 \ud3a9\ud0c0\uc774\ub4dc\ub3c4 \ub9c8\ucc2c\uac00\uc9c0\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud65c\ub3d9\ub7c9 \uc99d\uac00 \ub610\ub294 \uac10\uc18c\ub85c \uc778\ud574 \ud56d\uc0c1\uc131\uc758 \ubd88\uade0\ud615\uc774 \ubc1c\uc0dd\ud558\uba74 \ubd80\uc791\uc6a9\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud604\uc7ac\uc758 \uc548\uc804\uc131 \ud14c\uc2a4\ud2b8 \ubc29\uc2dd\uc73c\ub85c\ub294 \uc774\ub7ec\ud55c ‘\uacfc\uc7a5\ub41c \uc57d\ub9ac\ud559\uc801’ \ud604\uc0c1\uc744 \uc2dd\ubcc4\ud558\ub294 \uac83\uc774 \uc27d\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\ub2e8\ubc31\uc9c8\uacfc \ud3a9\ud0c0\uc774\ub4dc\uc758 \ud2b9\uc131\uc0c1 \uc77c\ub828\uc758 \uc0dd\ubb3c\ud559\uc801 \uc0ac\uac74\uc774 \uc5f0\uc1c4\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\uc5ec \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\uc73c\ubbc0\ub85c, \uc778\uccb4 \uac74\uac15\uc5d0 \ub300\ud55c \uc7a0\uc7ac\uc801 \uc704\ud574\uc131\uc744 \ud30c\uc545\ud558\ub824\uba74 \ucd1d\uccb4\uc801\uc778 \uc811\uadfc \ubc29\uc2dd\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc774\ub97c \uc704\ud574 \ucc28\uc138\ub300 \uc624\ubbf9\uc2a4 \uae30\uc220\uc774 \ud070 \ub3c4\uc6c0\uc774 \ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uac04\ub2e8\ud788 \ub9d0\ud574, \uc774\ub7ec\ud55c \uae30\uc220\uc744 \ud1b5\ud574 \uc720\uc804\uc790 \ubc0f \ub2e8\ubc31\uc9c8 \uc218\uc900\uc5d0\uc11c \ubc1c\uc0dd\ud558\ub294 \ubd84\uc790 \uc0ac\uac74\uc744 \ud3ec\uad04\uc801\uc73c\ub85c \ud30c\uc545\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc601\ud5a5\uc744 \ubc1b\ub294 \uc720\uc804\uc790 \ubc0f\/\ub610\ub294 \ub2e8\ubc31\uc9c8\uc758 \ub124\ud2b8\uc6cc\ud06c\uac00 \ud655\uc778\ub418\uba74, \uc774\ub294 \uac74\uac15\uc5d0 \uc545\uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4 \ubd84\uc790 \uc791\uc6a9 \ubc29\uc2dd\uacfc \uc5f0\uacb0\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uaddc\uc81c \ub3c5\uc131\ud559\uc5d0\uc11c \ud06c\uac8c \uac01\uad11\ubc1b\uace0 \uc788\ub294 \uc811\uadfc \ubc29\uc2dd\uc778 \ubd84\uc790 \uac1c\uc2dc \uc0ac\uac74\uc73c\ub85c\ubd80\ud130 \uac74\uac15\uc5d0 \ubbf8\uce58\ub294 \uc815\uc810 \ubd80\uc791\uc6a9\uc744 \uc608\uce21\ud558\ub294 \ubd80\uc791\uc6a9 \uacbd\ub85c(AOP) \uc811\uadfc \ubc29\uc2dd\uacfc \uc77c\uce58\ud569\ub2c8\ub2e4. \uc774\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uad6c\ud604\ud558\ub824\uba74 \uc774\ub7ec\ud55c \ubd84\uc57c\uc758 \uae30\uc220\uc744 \uac1c\ubc1c\ud558\ub294 \ub3d9\uc2dc\uc5d0 \ud14c\uc2a4\ud2b8 \ube44\uc6a9\uc774 \ub9ce\uc774 \ub4e4\uc9c0 \uc54a\ub3c4\ub85d \ud574\uc57c \ud569\ub2c8\ub2e4. \ub610\ud55c, \uc77c\ubd80 AOP\ub294 \uac1c\ubc1c \ubc0f \uac80\uc99d\uc774 \uc644\ub8cc\ub41c \ubc18\uba74 \ub2e4\ub978 AOP\ub294 \ub2e4\uc591\ud55c \uc218\uc6a9 \ubc0f \uac1c\ubc1c \ub2e8\uacc4\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\uc81c\ub85c \ub3c5\uc131\ud559\uc801 \ubd84\uc790 \uacbd\ub85c\ub97c AOP\ub85c \ub9e4\ud551\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc544\uc9c1 \uc0c1\ub2f9\ud55c \uc591\uc758 \uc791\uc5c5\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc774\ub7ec\ud55c \uc811\uadfc\ubc95\uc73c\ub85c\ub294 \uc544\uc9c1 \uc778\uccb4 \uac74\uac15\uc5d0 \ub300\ud55c \uc720\ud574\uc131\uc744 \uc27d\uac8c \ud655\uc778\ud560 \uc218 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \ud654\uc7a5\ud488 \uc131\ubd84\uc758 \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \uc81c\ud55c\ud558\uc5ec \ubd88\ud655\uc2e4\uc131\uc744 \uad00\ub9ac\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p> \n \n

\uacb0\ub860<\/h2> \n \n
\n
\"\"<\/figure> \n<\/div> \n \n

\uc704\uc5d0\uc11c \uc124\uba85\ud55c \ubc14\uc640 \uac19\uc774 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc740 \uac74\uac15 \uc704\ud5d8\uc744 \uc81c\ud55c\ud560 \uc218 \uc788\ub294 \uc5ec\ub7ec \uac00\uc9c0 \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud2b9\uc131\uc740 \ud654\uc7a5\ud488 \uc6d0\ub8cc\uc5d0 \ub300\ud55c \ub3d9\ubb3c \uc2e4\ud5d8 \uae08\uc9c0\uc5d0 \ube44\ucd94\uc5b4 \ubcfc \ub54c \ud2b9\ud788 \uc911\uc694\ud569\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc774\ub7ec\ud55c \ud2b9\uc131\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uc774\ub7ec\ud55c \uc131\ubd84\uc744 \ud06c\uac8c \ubcc0\uacbd\ud558\ub294 \uac83\uc740 \ud53c\ud574\uc57c \ud569\ub2c8\ub2e4. \uac04\ub2e8\ud788 \uc124\uba85\ud558\uba74 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4:<\/p> \n \n

    \n
  • \ud761\uc218\ub97c \ud06c\uac8c \uc99d\uac00\uc2dc\ud0a4\uae30 \uc704\ud55c \uad11\ubc94\uc704\ud55c \uc218\uc815 \uc5c6\uc74c – \uc774\ub294 \ub3c5\uc131\ud559\uc758 \uc911\uc2ec \ub3c4\uadf8\ub9c8(\uc81c\ud55c\ub41c \ub178\ucd9c = \uc81c\ud55c\ub41c \uc704\ud5d8)\ub97c \uc720\uc9c0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.<\/li> \n
  • \uc544\ubbf8\ub178\uc0b0\uc5d0 \ub300\ud55c \uc81c\ud55c\uc801\uc778 \ubcc0\ud615 – \ucc9c\uc5f0 \uc544\ubbf8\ub178\uc0b0\uc740 \ube60\ub974\uac8c \ub300\uc0ac\ub418\ub294 \ub3d9\uc548 \uc720\uc804 \ub3c5\uc131, \ubc1c\uc554\uc131 \ub610\ub294 \uc0dd\uc2dd \ub3c5\uc131 \ubb3c\uc9c8\uc774 \ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/li> \n
  • \ud2f0\ub85c\uc2e0, \ud2b8\ub9bd\ud1a0\ud310 \ubc0f \uc2dc\uc2a4\ud14c\uc778 \uc794\ub958\ub7c9 \uc81c\ud55c – \uad11\ub3c5\uc131 \uac00\ub2a5\uc131 \uc81c\ud55c<\/li> \n
  • \uc0dd\uc0b0 \uacf5\uc815\uc5d0 \uc815\ud654 \ub2e8\uacc4 \ud3ec\ud568 – \uc7a0\uc7ac\uc801\uc73c\ub85c \uc704\ud5d8\ud55c \ubd88\uc21c\ubb3c\uc758 \uc774\uc6d4\uc744 \uc81c\ud55c\ud569\ub2c8\ub2e4.<\/li> \n<\/ul> \n \n

    \uc774\ub7ec\ud55c \uace0\ub824 \uc0ac\ud56d\uc740 \ud654\uc7a5\ud488 \uc131\ubd84\uc5d0 \ub300\ud55c \ub3d9\ubb3c \uc2e4\ud5d8\uc774 \uae08\uc9c0\ub418\uc5b4 \ub3c5\uc131\ud559\uc790\uac00 \uc804\ud1b5\uc801\uc778 \ub3d9\ubb3c \ub3c5\uc131 \uc2e4\ud5d8 \uc774\uc678\uc758 \ub370\uc774\ud130\uc640 \ub3c4\uad6c\uc5d0 \uc758\uc874\ud574\uc57c \ud558\ub294 \uc0c1\ud669\uc5d0\uc11c \uc911\uc694\ud55c \uc758\ubbf8\ub97c \uac16\uc2b5\ub2c8\ub2e4. \ub610\ud55c \ud30c\ud2b8 1\uc5d0\uc11c \uc5b8\uae09\ud588\ub4ef\uc774 \ud654\uc7a5\ud488\uacfc \uc758\uc57d\ud488\uc740 \uc6a9\ub3c4\uc5d0 \ub530\ub77c \uad6c\ubd84\ub418\uba70, \uc774\ub294 \uc8fc\ub85c \ud6a8\ub2a5\uc5d0 \ub530\ub77c \uacb0\uc815\ub429\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud654\uc7a5\ud488 \uc2e4\ubb34\uadf8\ub8f9 \uacbd\uacc4 \uc81c\ud488 \ub9e4\ub274\uc5bc\uc5d0 \ub530\ub974\uba74 \uc57d\ub9ac \uc791\uc6a9\uc744 \ubc1c\ud718\ud558\uc5ec \uc0dd\ub9ac\uc801 \uae30\ub2a5\uc744 \ud68c\ubcf5, \uad50\uc815 \ub610\ub294 \uc218\uc815\ud558\ub294 \ubb3c\uc9c8\uc740 “\uadf8 \ud45c\ud604\uc5d0 \uc758\ud574” \ub610\ub294 “\uadf8 \uae30\ub2a5\uc5d0 \uc758\ud574” \uc2dd\ubcc4\ub429\ub2c8\ub2e4(\uc704\uc5d0\uc11c \uc124\uba85\ud55c \ubc14\uc640 \uac19\uc774 \uc8fc\uc7a5). \ud6c4\uc790\ub294 “\ud761\uc218, \ub18d\ub3c4, \ud22c\uc5ec \uacbd\ub85c, \uc801\uc6a9 \ube48\ub3c4, \uc801\uc6a9 \ubd80\uc704, \uce68\ud22c \uc815\ub3c4 \ub4f1 \uc81c\ud488\uc758 \ubaa8\ub4e0 \ud2b9\uc131\uc744 \uace0\ub824\ud558\uc5ec \ud3c9\uac00”\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc5b4\ub5a4 \uc131\ubd84\uc774 \uc758\uc57d\ud488 \ub610\ub294 \ud654\uc7a5\ud488\uc778\uc9c0 \ud310\ub2e8\ud560 \ub54c \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8 \ud2b9\uc131\uc774 \uc5b4\ub5bb\uac8c \uc5bd\ud600\uc11c \ub3c5\uc131\ud559\uc801 \ud504\ub85c\ud30c\uc77c\uc744 \uc774\ub04c\uc5b4\ub0b4\ub294\uc9c0 \uc774\ud574\ud558\ub294 \uc5ed\ud560\uc774 \uc911\uc694\ud574\uc84c\uc2b5\ub2c8\ub2e4.<\/p> \n \n

    \ucc38\uc870<\/h2> \n \n

    Choi, Y.L., Park, E.J., Kim, E., Na, D.H., and Shin, Y.H. (2014). \ucf5c\ub77c\uac90 \ud39c\ud0c0\ud3a9\ud0c0\uc774\ub4dc(KTTKS \ubc0f \ud314\ubbf8\ud1a0\uc77c-KTTKS)\uc758 \ud53c\ubd80 \uc548\uc815\uc131 \ubc0f \uc2dc\ud5d8\uad00 \ub0b4 \ud53c\ubd80 \ud22c\uacfc\uc131. Biomol. Ther. 22<\/em>, 321-327.<\/p> \n \n

    \uc720\ub7fd \uc758\uc57d\ud488\uccad (2011). ‘\uad11\uc548\uc804 \ud14c\uc2a4\ud2b8 \uc548\ub0b4\ub97c \uc704\ud55c \ucc38\uace0 \uc0ac\ud56d’\uc5d0 \ub300\ud55c \uc9c8\ubb38\uacfc \ub2f5\ubcc0.<\/p> \n \n

    Gocke, E., Albertini, S., Brendler-Schwaab, S., M\u00fcller, L., Suter, W., W\u00fcrgler, F.E. (1999). \uc0dd\uba85\uacf5\ud559 \uc720\ub798 \uc81c\ud488\uc758 \uc720\uc804\ub3c5\uc131 \ud14c\uc2a4\ud2b8: GUM \ud0dc\uc2a4\ud06c\ud3ec\uc2a4 \ubcf4\uace0\uc11c. Mutat. Res. – \ubb34\ud0d3 \ubaa9\uc0ac\ub2d8 436<\/em>, 137-156.<\/p> \n \n

    \ud5e8\ub9ac, B., \ud3ec\ud2f0, C., \uc54c\uc0b0\ud14c, K. (2009). \uad11\ud761\uc218 \ubc0f \uad11\uc548\uc815\uc131 \ub370\uc774\ud130\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc2e0\uc57d \ubd84\uc790\uc5d0 \ub300\ud55c \ud658\uc790\uc758 \uad11\uc548\uc804\uc131 \uc704\ud5d8\uc744 \ud3c9\uac00\ud560 \uc218 \uc788\ub098\uc694? J. Photochem. \ud3ec\ud1a0\ubc14\uc774\uc624\uc62c. 96<\/em>, 57-62.<\/p> \n \n

    Huby, R.D.J. (2000). \uc77c\ubd80 \ub2e8\ubc31\uc9c8\uc774 \uc54c\ub808\ub974\uae30 \uc720\ubc1c \ubb3c\uc9c8\uc778 \uc774\uc720\ub294? Toxicol. 55<\/em>, 235-246.<\/p> \n \n

    \uc870\ud654\uc5d0 \uad00\ud55c \uad6d\uc81c \ucee8\ud37c\ub7f0\uc2a4(2011). \uc0dd\uba85\uacf5\ud559 \uc720\ub798 \uc758\uc57d\ud488\uc758 \uc804\uc784\uc0c1 \uc548\uc804\uc131 \ud3c9\uac00.<\/p> \n \n

    \uc870\ud654\uc5d0 \uad00\ud55c \uad6d\uc81c \ucee8\ud37c\ub7f0\uc2a4(2013). \uc758\uc57d\ud488\uc758 \uad11\uc548\uc804\uc131 \ud3c9\uac00.<\/p> \n \n

    Roberts, D.W., Basketter, D., Kimber, I., White, J., McFadden, J., White, I.R. (2012). \uc811\ucd09 \uc54c\ub808\ub974\uac90\uc73c\ub85c\uc11c\uc758 \uba54\ud0c0\uc911\uc544\ud669\uc0b0\ub098\ud2b8\ub968 – \ub2e8\ubc31\uc9c8 \ubcc0\ud615\uc758 \ub4dc\ubb38 \ud654\ud559\uc801 \uba54\ucee4\ub2c8\uc998\uc758 \ud55c \uc608\uc785\ub2c8\ub2e4. \ud53c\ubd80\uc5fc 66<\/em>, 123-127\uc5d0 \ubb38\uc758\ud558\uc138\uc694. SCCS (2014). \uac00\uc218\ubd84\ud574 \ubc00 \ub2e8\ubc31\uc9c8\uc5d0 \ub300\ud55c \uc758\uacac.<\/p> \n \n

    \uc774 \uae00\uc740 \uc804 \uc218\uc11d \ub3c5\uc131\ud559\uc790\uc600\ub358 \ubcf4\ub9ac\uc2a4 \ud06c\ub9ac\ubcf4\uc2dc\uc608\ud504 \ubc15\uc0ac\uac00 \ubc14\uc774\uc624\ub9ac\uc6b0\uc2a4 \uc7ac\uc9c1 \uc2dc\uc808\uc5d0 \uc791\uc131\ud55c \uae00\uc785\ub2c8\ub2e4.<\/p> \n","protected":false},"excerpt":{"rendered":"

    \uc18c\uac1c \uc774\uc804 \ud30c\ud2b8\uc5d0\uc11c\ub294 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc774 \ud2b9\ud788 \ub178\ud654 \ubc29\uc9c0 \ud65c\ub3d9\uc73c\ub85c \uc778\ud574 \ud765\ubbf8\ub85c\uc6b4 \ud654\uc7a5\ud488 \uc131\ubd84\uc774\ub77c\ub294 \uc810\uc744 \uac15\uc870\ud588\uc2b5\ub2c8\ub2e4. \uc774\ubbf8 \uc218\ub9ce\uc740 \ud3a9\ud0c0\uc774\ub4dc \uae30\ubc18 \ud654\uc7a5\ud488 \uc6d0\ub8cc\uac00 \uc2dc\uc911\uc5d0 \ub098\uc640…<\/p>\n","protected":false},"author":2,"featured_media":40905,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[2295],"tags":[],"ppma_author":[2288],"class_list":["post-48999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2295","author-christophe-brault-chevalier"],"acf":[],"yoast_head":"\n\ud654\uc7a5\ud488\uc758 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8 - 2\ubd80(\uc548\uc804 \uce21\uba74) - Biorius<\/title>\n<meta name=\"description\" content=\"\ud3a9\ud0c0\uc774\ub4dc\uc640 \ub2e8\ubc31\uc9c8\uc740 \ud654\uc7a5\ud488 \uc6d0\ub8cc\uc640 \uc81c\ud488\uc5d0 \uc810\uc810 \ub354 \ub9ce\uc774 \uc0ac\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \uc815\ub9d0 \uacb0\ubc31\ud560\uae4c\uc694? 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